analgesic and anti-inflammatory activity of teucrium chamaedrys leaves aqueous extract in male rats

objective(s) current study was undertaken to investigate the analgesic and anti-inflammatory effects of the aqueous extract of teucrium chamaedrys in mice and rats. materials and methods for evaluating of analgesic and anti-inflammatory activity, we used the carrageenan- and dextran-induced paw oedema, acetic acid-induced writhing, tail flick and formalin pain tests. results the extract of t. chamaedrys (50-200 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant (p< 0.01) inhibition of the second phase response in the formalin pain model, while only the high dose (200 mg/kg) of the extract showed an analgesic effect in the first phase. the extract also inhibited acetic acid-induced abdominal writhes in a dose-dependent manner. the tail flick latency was dose dependently enhanced by the extract but this was significantly (p< 0.05) lower than that produced by morphine (10 mg/kg). the extract (25-250 mg/kg) administered 1 hr before carrageenan-induced paw swelling produced a dose dependent inhibition of the oedema. no effect was observed with the dextran-induced oedema model. results of the phytochemical screening show the presence of alkaloids, flavonoids and triterpenoids in the extract. conclusion the data obtained also suggest that the anti-inflammatory and analgesic effects of the extract may be mediated via both peripheral and central mechanisms. the role of alkaloids, flavonoids and triterpenoids will evaluate in future studies.